{"id":7084,"date":"2021-02-12T09:42:01","date_gmt":"2021-02-12T08:42:01","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/"},"modified":"2022-10-03T11:17:03","modified_gmt":"2022-10-03T09:17:03","slug":"patients-with-heart-failure-and-iron-supplementation","status":"publish","type":"in-un-flash","link":"https:\/\/www.agingproject.uniupo.it\/en\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/","title":{"rendered":"Iron Deficiency in Elderly Patients with Heart Failure"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Iron is not only fundamental for hemoglobin synthesis, but also for the production of other very important proteins. Its role is therefore not limited to hematopoiesis, as it has a broader function in human physiology. Consequently, iron deficiency may have detrimental effects beyond just the development of sideropenic anemia.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In recent years, for instance, different studies have demonstrated that iron deficiency has a negative effect on patients with heart failure, even in those with normal hemoglobin levels. A recent double-blind placebo-controlled randomized clinical trial (AFFIRM-AHF), published in The Lancet in 2020, evaluated the effect of intravenous iron supplementation in sideropenic subjects admitted to hospital due to heart failure.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">1110 patients were randomly selected for either a placebo or treatment of intravenous ferric carboxymaltose. Only around half of them had a clinically overt iron deficiency. Iron supplementation was effective in lowering the risk of hospital re-admission due to heart failure; conversely, no effect was demonstrated with respect to cardiovascular mortality. The safety profile was comparable between the two groups.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the basis of this study, sideropenic patients with heart failure should be considered for iron supplementation. Though ineffective in reducing the risk of cardiovascular mortality, iron supplementation can reduce the number of hospitalizations due to heart failure. <\/span><\/p>\n","protected":false},"author":4,"featured_media":0,"template":"","class_list":["post-7084","in-un-flash","type-in-un-flash","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Iron Deficiency in Elderly Patients with Heart Failure | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Iron supplementation has been shown to be effective in reducing the risk of re-hospitalization of patients for heart failure\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Iron Deficiency in Elderly Patients with Heart Failure\" \/>\n<meta property=\"og:description\" content=\"Iron supplementation has been shown to be effective in reducing the risk of re-hospitalization of patients for heart failure\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-03T09:17:03+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/\",\"name\":\"Iron Deficiency in Elderly Patients with Heart Failure | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2021-02-12T08:42:01+00:00\",\"dateModified\":\"2022-10-03T09:17:03+00:00\",\"description\":\"Iron supplementation has been shown to be effective in reducing the risk of re-hospitalization of patients for heart failure\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/in-un-flash\/patients-with-heart-failure-and-iron-supplementation\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Iron Deficiency in Elderly Patients with Heart Failure\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - 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