{"id":6392,"date":"2020-02-15T15:19:17","date_gmt":"2020-02-15T14:19:17","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/?post_type=pubblicazione&p=6392"},"modified":"2022-11-01T10:46:51","modified_gmt":"2022-11-01T09:46:51","slug":"nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/","title":{"rendered":"Nerve conduction, circulating osteopontin and taxane-induced neuropathy in breast cancer patients"},"content":{"rendered":"

Objective<\/span><\/h2>\n
\n

Chemotherapy-induced peripheral\u00a0neuropathy\u00a0(CIPN) is a disabling complication related to\u00a0taxanes. Underlying mechanisms are not completely understood and no specific treatment exists. We investigated the role of\u00a0nerve conduction studies\u00a0(NCS) and of serum\u00a0osteopontin\u00a0(OPN) measurement as a means to stratify the risk of developing taxane-induced neuropathy (TIN).<\/p>\n<\/div>\n

\n

Methods<\/h3>\n

We enrolled 50\u00a0women with breast cancer treated with taxanes (docetaxel or paclitaxel) in a 3-month prospective study. They were evaluated before chemotherapy (time-point T0) and followed up at 1 (T1) and 3 (T2) months with clinical examinations\/scales, quality of life (QoL) questionnaires, NCS, and serum OPN dosages.<\/p>\n<\/div>\n

\n

Results<\/h3>\n

A reduction of\u00a0sural\u00a0and superficial peroneal sensory action potentials was seen at T1, with a progression at T2 (P<\/em>\u00a0<\u00a00.001). In contrast, a significant impact of neuropathic symptoms on QoL only occurred at T2 (P<\/em>\u00a0<\u00a00.01). OPN levels at T0 inversely correlated to axonal loss in the\u00a0sural nerve\u00a0(T0\u2013T2,\u00a0P<\/em>\u00a0<\u00a00.01). OPN levels at T0 were lower in the intermediate and poor outcome patient subgroups, compared to the good outcome subgroup, as specifically defined (P<\/em>\u00a0<\u00a00.05).<\/p>\n<\/div>\n

\n

Conclusion<\/h3>\n

Lower limb NCS changes occurred earlier than the detrimental effects of TIN on patients\u2019 QoL. Low serum OPN levels before chemotherapy may represent a novel biomarker of TIN risk.<\/p>\n<\/div>\n","protected":false},"template":"","categoria-pubblicazioni":[],"class_list":["post-6392","pubblicazione","type-pubblicazione","status-publish","hentry"],"yoast_head":"\nNerve conduction, circulating osteopontin and taxane-induced neuropathy in breast cancer patients | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"3-month prospective study on 50\u00a0women with breast cancer treated with taxanes to stratify the risk of developing taxane-induced neuropathy\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nerve conduction, circulating osteopontin and taxane-induced neuropathy in breast cancer patients\" \/>\n<meta property=\"og:description\" content=\"3-month prospective study on 50\u00a0women with breast cancer treated with taxanes to stratify the risk of developing taxane-induced neuropathy\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-01T09:46:51+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/\",\"name\":\"Nerve conduction, circulating osteopontin and taxane-induced neuropathy in breast cancer patients | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2020-02-15T14:19:17+00:00\",\"dateModified\":\"2022-11-01T09:46:51+00:00\",\"description\":\"3-month prospective study on 50\u00a0women with breast cancer treated with taxanes to stratify the risk of developing taxane-induced neuropathy\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/nerve-conduction-circulating-osteopontin-and-taxane-induced-neuropathy-in-breast-cancer-patients\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Nerve conduction, circulating osteopontin and taxane-induced neuropathy in breast cancer patients\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - 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