{"id":6399,"date":"2020-07-15T15:58:18","date_gmt":"2020-07-15T13:58:18","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/?post_type=pubblicazione&#038;p=6399"},"modified":"2022-11-01T10:39:07","modified_gmt":"2022-11-01T09:39:07","slug":"cortical-visuomotor-interactions-in-freezing-of-gait","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/cortical-visuomotor-interactions-in-freezing-of-gait\/","title":{"rendered":"Cortical visuomotor interactions in Freezing of Gait"},"content":{"rendered":"<h3>Objectives<\/h3>\n<p>Altered cortical visuomotor integration has been involved in the pathophysiology of freezing of gait (FoG) in parkinsonism. The aim of this study was to assess the connections between the primary visual (V1) and motor (M1) areas with a paired-pulse, twin-coil transcranial magnetic stimulation (TMS) technique in patients with FoG.<\/p>\n<h3>Methods<\/h3>\n<p>Twelve Parkinson&#8217;s disease (PD) patients suffering from levodopa-responsive-FoG (off-FoG) were compared with 12 PD patients without FoG and 12 healthy subjects of similar age\/sex. In the \u201coff\u201d condition, visuomotor connections (VMCs) were assessed bilaterally. A conditioning stimulus over the V1 phosphene hotspot was followed at interstimulus intervals (ISIs) of 18 and 40 ms by a test stimulus over M1, to elicit motor evoked potentials (MEPs) in the contralateral first dorsal interosseous muscle.<\/p>\n<h3><strong>Results<\/strong><\/h3>\n<p>Significant (P &lt; 0.01), bilateral effects due to VMCs were detected in all three groups, consisting of a MEP suppression at ISI 18 and 40 ms. However, in PD patients with FoG, the MEP suppression was significantly (P &lt; 0.05) enhanced, both at ISI 18\u201340 ms, in comparison with the other two groups. The phenomenon was limited to the right hemisphere.<\/p>\n<h3>Conclusions<\/h3>\n<p>PD patients with FoG showed an excessive inhibitory response of the right M1 to inputs travelling from V1 at given ISIs. Right-sided alterations of the cortical visuomotor integration may contribute to the pathophysiology of FoG.<\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[],"class_list":["post-6399","pubblicazione","type-pubblicazione","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cortical visuomotor interactions in Freezing of Gait | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Assessment on the connections between the primary visual and motor areas with a paired-pulse, twin-coil transcranial magnetic stimulation technique\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cortical visuomotor interactions in Freezing of Gait\" \/>\n<meta property=\"og:description\" content=\"Assessment on the connections between the primary visual and motor areas with a paired-pulse, twin-coil transcranial magnetic stimulation technique\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-01T09:39:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/\",\"name\":\"Cortical visuomotor interactions in Freezing of Gait | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2020-07-15T13:58:18+00:00\",\"dateModified\":\"2022-11-01T09:39:07+00:00\",\"description\":\"Assessment on the connections between the primary visual and motor areas with a paired-pulse, twin-coil transcranial magnetic stimulation technique\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/cortical-visuomotor-interactions-in-freezing-of-gait\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Cortical visuomotor interactions in Freezing of Gait\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - 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