{"id":6523,"date":"2021-01-04T17:26:18","date_gmt":"2021-01-04T16:26:18","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/?post_type=pubblicazione&p=6523"},"modified":"2021-04-06T14:51:28","modified_gmt":"2021-04-06T12:51:28","slug":"mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/","title":{"rendered":"Mining cancer biology through bioinformatic analysis of proteomic data"},"content":{"rendered":"

Introduction<\/h3>\n

Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer. With the advent of high-resolution mass spectrometers, able to identify thousands of proteins in complex biological samples, only the application of bioinformatics can lead to the interpretation of data which can be relevant for cancer research.<\/p>\n

Areas covered<\/h3>\n

Here, we give an overview of the current bioinformatic tools used in cancer proteomics. Moreover, we describe their applications in cancer proteomics studies of cell lines, serum, and tissues, highlighting recent results and critically evaluating their outcomes.<\/p>\n

Expert opinion<\/h3>\n

The use of bioinformatic tools is a fundamental step in order to manage the large amount of proteins (from hundreds to thousands) that can be identified and quantified in a cancer biological samples by proteomics. To handle this challenge and obtain useful data for translational medicine, it is important the combined use of different bioinformatic tools. Moreover, a particular attention to the global experimental design, and the integration of multidisciplinary skills are essential for best setting of tool parameters and best interpretation of bioinformatics output.<\/p>\n

 <\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[5055],"class_list":["post-6523","pubblicazione","type-pubblicazione","status-publish","hentry","categoria-pubblicazioni-target-aging"],"yoast_head":"\nMining cancer biology through bioinformatic analysis of proteomic data | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mining cancer biology through bioinformatic analysis of proteomic data\" \/>\n<meta property=\"og:description\" content=\"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-06T12:51:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/\",\"name\":\"Mining cancer biology through bioinformatic analysis of proteomic data | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2021-01-04T16:26:18+00:00\",\"dateModified\":\"2021-04-06T12:51:28+00:00\",\"description\":\"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Mining cancer biology through bioinformatic analysis of proteomic data\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png\",\"contentUrl\":\"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png\",\"width\":622,\"height\":213,\"caption\":\"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale\"},\"image\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/ProjectAging\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Mining cancer biology through bioinformatic analysis of proteomic data | Aging Project Uniupo","description":"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/","og_locale":"en_US","og_type":"article","og_title":"Mining cancer biology through bioinformatic analysis of proteomic data","og_description":"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.","og_url":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/","og_site_name":"Aging Project Uniupo","article_modified_time":"2021-04-06T12:51:28+00:00","twitter_card":"summary_large_image","twitter_site":"@ProjectAging","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/","url":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/","name":"Mining cancer biology through bioinformatic analysis of proteomic data | Aging Project Uniupo","isPartOf":{"@id":"https:\/\/www.agingproject.uniupo.it\/#website"},"datePublished":"2021-01-04T16:26:18+00:00","dateModified":"2021-04-06T12:51:28+00:00","description":"Discovery proteomics for cancer research generates complex datasets of diagnostic, prognostic, and therapeutic significance in human cancer.","breadcrumb":{"@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/mining-cancer-biology-through-bioinformatic-analysis-of-proteomic-data\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.agingproject.uniupo.it\/homepage\/"},{"@type":"ListItem","position":2,"name":"Pubblicazioni","item":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/"},{"@type":"ListItem","position":3,"name":"Mining cancer biology through bioinformatic analysis of proteomic data"}]},{"@type":"WebSite","@id":"https:\/\/www.agingproject.uniupo.it\/#website","url":"https:\/\/www.agingproject.uniupo.it\/","name":"Aging Project Uniupo","description":"Facing the challenge of longevity, through interdisciplinary research","publisher":{"@id":"https:\/\/www.agingproject.uniupo.it\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.agingproject.uniupo.it\/#organization","name":"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale","url":"https:\/\/www.agingproject.uniupo.it\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/","url":"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png","contentUrl":"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png","width":622,"height":213,"caption":"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale"},"image":{"@id":"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/ProjectAging"]}]}},"_links":{"self":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/pubblicazione\/6523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/pubblicazione"}],"about":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/types\/pubblicazione"}],"wp:attachment":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/media?parent=6523"}],"wp:term":[{"taxonomy":"categoria-pubblicazioni","embeddable":true,"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/categoria-pubblicazioni?post=6523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}