{"id":6565,"date":"2021-01-08T18:41:15","date_gmt":"2021-01-08T17:41:15","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/?post_type=pubblicazione&p=6565"},"modified":"2021-04-13T20:00:19","modified_gmt":"2021-04-13T18:00:19","slug":"is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/","title":{"rendered":"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials"},"content":{"rendered":"

Background:<\/strong> Global dietary patterns have gradually shifted toward a ‘western type’ with progressive increases in rates of metabolic imbalance. Recently, animal and human studies have revealed positive effects of caloric restriction (CR) on many health domains, giving new knowledge for prevention of ill and health promotion.<\/p>\n

Methods<\/strong>: We conducted a systematic review (SR) of randomized controlled trials (RCTs) investigating the role of CR on health status in adults. A meta-analysis was performed on anthropometric, cardiovascular and metabolic outcomes.<\/p>\n

Results:<\/strong> A total of 29 articles were retrieved including data from eight RCTs. All included RCTs were at low risk for performance bias related to objective outcomes. Collectively, articles included 704 subjects. Among the 334 subjects subjected to CR, the compliance with the intervention appeared generally high. Meta-analyses proved benefit of CR on reduction of body weight, BMI, fat mass, total cholesterol, while a minor impact was shown for LDL, fasting glucose and insulin levels. No effect emerged for HDL and blood pressure after CR. Data were insufficient for other hormone variables in relation to meta-analysis of CR effects.<\/p>\n

Conclusion<\/strong>: CR is a nutritional pattern linked to improved cardiometabolic status. However, evidence is limited on the multidimensional aspects of health and requires more studies of high quality to identify the precise impact of CR on health status and longevity.<\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[5053],"class_list":["post-6565","pubblicazione","type-pubblicazione","status-publish","hentry","categoria-pubblicazioni-modesthe"],"yoast_head":"\nIs Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials\" \/>\n<meta property=\"og:description\" content=\"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2021-04-13T18:00:19+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/\",\"name\":\"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2021-01-08T17:41:15+00:00\",\"dateModified\":\"2021-04-13T18:00:19+00:00\",\"description\":\"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png\",\"contentUrl\":\"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png\",\"width\":622,\"height\":213,\"caption\":\"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale\"},\"image\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/x.com\/ProjectAging\"]}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Aging Project Uniupo","description":"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/","og_locale":"en_US","og_type":"article","og_title":"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials","og_description":"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults","og_url":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/","og_site_name":"Aging Project Uniupo","article_modified_time":"2021-04-13T18:00:19+00:00","twitter_card":"summary_large_image","twitter_site":"@ProjectAging","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/","url":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/","name":"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials | Aging Project Uniupo","isPartOf":{"@id":"https:\/\/www.agingproject.uniupo.it\/#website"},"datePublished":"2021-01-08T17:41:15+00:00","dateModified":"2021-04-13T18:00:19+00:00","description":"Systematic review (SR) of randomized controlled trials (RCTs) investigating the role of caloric restriction (CR) on health status in adults","breadcrumb":{"@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/is-caloric-restriction-associated-with-better-healthy-aging-outcomes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.agingproject.uniupo.it\/homepage\/"},{"@type":"ListItem","position":2,"name":"Pubblicazioni","item":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/"},{"@type":"ListItem","position":3,"name":"Is Caloric Restriction Associated with Better Healthy Aging Outcomes? A Systematic Review and Meta-Analysis of Randomized Controlled Trials"}]},{"@type":"WebSite","@id":"https:\/\/www.agingproject.uniupo.it\/#website","url":"https:\/\/www.agingproject.uniupo.it\/","name":"Aging Project Uniupo","description":"Facing the challenge of longevity, through interdisciplinary research","publisher":{"@id":"https:\/\/www.agingproject.uniupo.it\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.agingproject.uniupo.it\/#organization","name":"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale","url":"https:\/\/www.agingproject.uniupo.it\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/","url":"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png","contentUrl":"https:\/\/www.agingproject.uniupo.it\/wp-content\/uploads\/2019\/12\/logo-upo-orizzontale.png","width":622,"height":213,"caption":"Aging Project - DIMET - Universit\u00e0 del Piemonte Orientale"},"image":{"@id":"https:\/\/www.agingproject.uniupo.it\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/ProjectAging"]}]}},"_links":{"self":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/pubblicazione\/6565","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/pubblicazione"}],"about":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/types\/pubblicazione"}],"wp:attachment":[{"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/media?parent=6565"}],"wp:term":[{"taxonomy":"categoria-pubblicazioni","embeddable":true,"href":"https:\/\/www.agingproject.uniupo.it\/en\/wp-json\/wp\/v2\/categoria-pubblicazioni?post=6565"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}