{"id":6575,"date":"2021-01-10T11:57:42","date_gmt":"2021-01-10T10:57:42","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/?post_type=pubblicazione&p=6575"},"modified":"2021-02-04T19:12:11","modified_gmt":"2021-02-04T18:12:11","slug":"war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/","title":{"rendered":"“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients"},"content":{"rendered":"

In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction, with a focus on direct viral infection and cytokine-mediated injury. Entanglement between inflammation and coagulation and resistance to heparin provide a rationale to consider other therapeutic approaches in order to preserve endothelial function and limit microthrombosis, especially in severe forms. These strategies include nebulized heparin, N-acetylcysteine, plasma exchange and\/or fresh frozen plasma, plasma derivatives to increase the level of endogenous anticoagulants (tissue factor pathway inhibitor, activated protein C, thrombomodulin, antithrombin), dipyridamole, complement blockers, different types of stem cells, and extracellular vesicles. An integrated therapy including these drugs has the potential to improve outcomes in COVID-19.<\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[5051],"class_list":["post-6575","pubblicazione","type-pubblicazione","status-publish","hentry","categoria-pubblicazioni-ame"],"yoast_head":"\n"War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Thromboinflammation in COVID-19 and endothelial injury as a key point for the development offor the development of lung and distant organ dysfunction.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\""War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients\" \/>\n<meta property=\"og:description\" content=\"Thromboinflammation in COVID-19 and endothelial injury as a key point for the development offor the development of lung and distant organ dysfunction.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-04T18:12:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/\",\"name\":\"\\\"War to the knife\\\" against thromboinflammation to protect endothelial function of COVID-19 patients | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2021-01-10T10:57:42+00:00\",\"dateModified\":\"2021-02-04T18:12:11+00:00\",\"description\":\"Thromboinflammation in COVID-19 and endothelial injury as a key point for the development offor the development of lung and distant organ dysfunction.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/war-to-the-knife-against-thromboinflammation-to-protect-endothelial-function-of-covid-19-patients\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - 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