{"id":7658,"date":"2021-03-31T16:50:31","date_gmt":"2021-03-31T14:50:31","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/circulating-platelet-derived-extracellular-vesicles-are-a-hallmark-of-sars-cov-2-infection\/"},"modified":"2021-03-31T16:50:42","modified_gmt":"2021-03-31T14:50:42","slug":"circulating-platelet-derived-extracellular-vesicles-are-a-hallmark-of-sars-cov-2-infection","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/circulating-platelet-derived-extracellular-vesicles-are-a-hallmark-of-sars-cov-2-infection\/","title":{"rendered":"Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection"},"content":{"rendered":"<p>Sars-Cov-2 infection causes fever and cough that may rapidly lead to acute respiratory distress syndrome (ARDS).<\/p>\n<p>Few biomarkers have been identified but, unfortunately, these are individually poorly specific, and novel biomarkers are needed to better predict patient outcome. The aim of this study was to evaluate the diagnostic performance of circulating platelets (PLT)-derived extracellular vesicles (EVs) as biomarkers for Sars-Cov-2 infection, by setting a rapid and reliable test on unmanipulated blood samples. PLT-EVs were quantified by flow cytometry on two independent cohorts of Sars-CoV-2+ (n = 69), Sars-Cov-2\u2212 (n = 62) hospitalized patients, and healthy controls. Diagnostic performance of PLT-EVs was evaluated by receiver operating characteristic (ROC) curve. PLT-EVs count were higher in Sars-Cov-2+ compared to Sars-Cov-2\u2212 patients or HC. ROC analysis of the combined cohorts showed an AUC = 0.79 and an optimal cut-off value of 1472 EVs\/\u03bcL, with 75% sensitivity and 74% specificity.<\/p>\n<p>These data suggest that PLT-EVs might be an interesting biomarker deserving further investigations to test their predictive power.<\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[5054],"class_list":["post-7658","pubblicazione","type-pubblicazione","status-publish","hentry","categoria-pubblicazioni-neuroaging"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v26.7) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Circulating Platelet-Derived Extracellular Vesicles Are a Hallmark of Sars-Cov-2 Infection | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"The aim of this study was to evaluate the diagnostic performance of circulating platelets-derived extracellular vesicles as biomarkers for Sars-Cov-2 infection\" \/>\n<meta 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