{"id":8219,"date":"2021-05-25T01:16:59","date_gmt":"2021-05-24T23:16:59","guid":{"rendered":"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/"},"modified":"2021-05-25T01:16:59","modified_gmt":"2021-05-24T23:16:59","slug":"polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives","status":"publish","type":"pubblicazione","link":"https:\/\/www.agingproject.uniupo.it\/en\/research\/publications\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/","title":{"rendered":"Polymorphisms of Dopamine Receptor Genes and Parkinson\u2019s Disease: Clinical Relevance and Future Perspectives"},"content":{"rendered":"

Background<\/h3>\n

Parkinson\u2019s disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor symptoms, and treatment relies on dopaminergic replacement. Beyond a common pathological hallmark, PD patients may present differences in both clinical progression and response to drug therapy that are partly affected by genetic factors. Despite extensive knowledge on genetic variability of dopaminergic receptors (DR), few studies have addressed their relevance as possible influencers of clinical heterogeneity in PD patients.<\/p>\n

The study<\/h3>\n

In this review, we summarized available evidence regarding the role of genetic polymorphisms in DR as possible determinants of PD development, progression and treatment response. Moreover, we examined the role of DR in the modulation of peripheral immunity, in light of the emerging role of the peripheral immune system in PD pathophysiology. A better understanding of all these aspects represents an important step towards the development of precise and personalized disease-modifying therapies for PD.<\/p>\n","protected":false},"template":"","categoria-pubblicazioni":[5054],"class_list":["post-8219","pubblicazione","type-pubblicazione","status-publish","hentry","categoria-pubblicazioni-neuroaging"],"yoast_head":"\nPolymorphisms of Dopamine Receptor Genes and Parkinson\u2019s Disease: Clinical Relevance and Future Perspectives | Aging Project Uniupo<\/title>\n<meta name=\"description\" content=\"Dopaminergic receptor variability may play a role in the variability in progression and response to therapy in Parkinson's disease.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Polymorphisms of Dopamine Receptor Genes and Parkinson\u2019s Disease: Clinical Relevance and Future Perspectives\" \/>\n<meta property=\"og:description\" content=\"Dopaminergic receptor variability may play a role in the variability in progression and response to therapy in Parkinson's disease.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/\" \/>\n<meta property=\"og:site_name\" content=\"Aging Project Uniupo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ProjectAging\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/\",\"name\":\"Polymorphisms of Dopamine Receptor Genes and Parkinson\u2019s Disease: Clinical Relevance and Future Perspectives | Aging Project Uniupo\",\"isPartOf\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\"},\"datePublished\":\"2021-05-24T23:16:59+00:00\",\"description\":\"Dopaminergic receptor variability may play a role in the variability in progression and response to therapy in Parkinson's disease.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/polymorphisms-of-dopamine-receptor-genes-and-parkinsons-disease-clinical-relevance-and-future-perspectives\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/homepage\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/www.agingproject.uniupo.it\/la-ricerca\/pubblicazioni\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Polymorphisms of Dopamine Receptor Genes and Parkinson\u2019s Disease: Clinical Relevance and Future Perspectives\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#website\",\"url\":\"https:\/\/www.agingproject.uniupo.it\/\",\"name\":\"Aging Project Uniupo\",\"description\":\"Facing the challenge of longevity, through interdisciplinary research\",\"publisher\":{\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.agingproject.uniupo.it\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.agingproject.uniupo.it\/#organization\",\"name\":\"Aging Project - 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