Feba M. Varughese - Aging project UniUPO

I am keen to learn new things in both professional and personal life. Being adaptable and flexible has enabled me to challenge myself in difficult situations and make me more independent. I love traveling to see new places and experience the culture, beauty, and food in different regions.

Academic Year: 2019/2020

Curriculum: Physiopathology of aging

Tutor: Alessandra Gennari

Research Topic

Impact of Cellular Senescence on response to preoperative Chemotherapy in the aging women
with early Breast Cancer.
Cellular senescence is a complex tumor-suppressive mechanism induced by various cellular stresses
characterized by irreversible proliferation arrest, changes in morphology and gene expression.
Senescent cells are metabolically active, remain viable and are resistant to apoptosis. Despite growth
suppression, senescent cancer cells promote tumor formation and recurrence by producing inflammatory cytokines, proteases, and growth factors; this phenomenon termed as the SASP (senescence‐associated secretory phenotype).
When cancer cells experience non-lethal doses of Chemotherapy (CT) may be due to rapid decline of
drug concentration during treatment and can enter a senescence-like state, referred to as Chemotherapy-induced senescence (CIS). Clinically, there is growing evidence that therapy-induced senescence occurs in tumors and is associated with improved clinical outcomes.
The main goal of this project is to analyze cell senescence after neoadjuvant treatment in early Breast Cancer (BC) patient’s candidate to preoperative CT.
Two main objectives of this study as follows: -
1) To evaluate the impact of senescent cells after neoadjuvant chemotherapy in patients with
early Breast Cancer.
2) To examine the innate immune-mediated clearance of senescent cells.