Preventing c2c12 muscular cells damage combining magnesium and potassium with vitamin D3 and curcumin

Background

Physical activity is defined as any bodily movement produced by skeletal muscles which causes energy consumption; moderate and constant physical activity is known to be beneficial and to slow the muscle loss process associated with aging.

Aim

The aim of the present study was to test, in an in vitro exercise model, the biological effects of a new formulation composed of magnesium and potassium combined with vitamin D and curcumin created to support muscle activity and to prevent hypercontraction damage.

Methods

C2C12 cells were treated with vitamin D, buffered magnesium bisglycinate, curcumin, and potassium citrate. Cell viability, morpho-functional changes, calcium and magnesium movements, and the main kinases involved in glucose uptake were analyzed. The glycogen level and lactate were also evaluated.

Results

Important results about a positive effect on mitochondrial activity, ATP production, oxygen consumption and in the physiological differentiation of C2C12 cells were obtained. Further experiments were performed under conditions that mimic the biological aspects of strenuous exercise. The combination of magnesium, vitamin D3, curcumin, and potassium citrate revealed beneficial effects on skeletal muscle cells under physiological conditions as well as while mimicking intense activity. In particular, in an in vitro model, they were able to control the hypercontraction, restoring ion fluxes, reducing inflammation signaling and supporting the main mechanism involved on aerobic activity.

Conclusion

Our results have indicated for the first time that this new combination could be considered as a new nutraceutical formulation to improve physical performance and muscle recovery.

Reference:

Molinari C, Ruga S, Farghali M, Galla R, Bassiouny A, Uberti F. Preventing c2c12 muscular cells damage combining magnesium and potassium with vitamin D3 and curcumin. Journal of Traditional and Complementary Medicine. 2021


Iscriviti alla Newsletter

* Richiesti

Scegli la newsletter

Consenso all’utilizzo dei datiAging Project userà le informazioni che fornisci al solo scopo di inviarti la newsletter richiesta.

Puoi annullare l'iscrizione in qualsiasi momento cliccando sul link che trovi nel footer dell'email. Per informazioni sulla Privacy Policy clicca qui.

Cliccando su "Acconsenti", accetti anche che le tue informazioni saiano trasferite a Mailchimp per l'elaborazione. Ulteriori informazioni sulle privacy di Mailchimp qui